“Behandling av kvinner i overgangsalderen med Femarelle® øker benmassen uten uønsket østrogeneffekt.”
Tofupill/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator- like substance for the treatment of postmenopausal bone loss.
After 12 months of treatment, BMD had increased in the study group by 3.6% in the lumbar
spine (P = 0.039) and by 2.0% in the femoral neck (NS). In the low-dose group, BMD had
decreased in the lumbar spine by 0.6% (NS) and by 0.6% in the femoral neck (NS).
Comparison of the change in bone density between the groups yielded a significant
difference for the lumbar spine (P = 0.037). Neither group showed a change in endometrial
thickness and sex hormone levels nor reported any side effects of treatment.